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SML1770 Sigma-Aldrich

PhiKan083 hydrochloride

≥98% (HPLC)

Synonym: 9-Ethyl-N-methyl-9H-Carbazole-3-methanamine hydrochloride, PK-083 hydrochloride, PK083 hydrochloride, PhiKan-083 hydrochloride

  • CAS Number 1050480-30-2

  • Empirical Formula (Hill Notation) C16H18N2 · HCl

  • Molecular Weight 274.79

  •  MDL number MFCD07168924

  •  NACRES NA.77

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Properties

Quality Level   100
assay   ≥98% (HPLC)
form   powder
color   white to beige
solubility   H2O: 2 mg/mL, clear
storage temp.   2-8°C
SMILES string   CNCC1=CC2=C(C=C1)N(CC)C3=C2C=CC=C3.[H]Cl

Description

Biochem/physiol Actions

PhiKan083 is a small molecule that binds within a cavity on the surface of Y220C-mutated p53. This mutation, which is not involved in DNA interaction, causes a destabilization of the protein. PhiKan083 binding acts to stabilize the mutant p53 and slow the rate of denaturation.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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