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SML1839 Sigma-Aldrich

PFM39

≥98% (HPLC)

Synonym: (5Z)-2-Amino-5-[(4-aminophenyl)methylene]-4(5H)-thiazolone, 5-(4-Aminobenzylidene)-2-iminothiazolidin-4-one

  • CAS Number 1310744-67-2

  • Empirical Formula (Hill Notation) C10H9N3OS

  • Molecular Weight 219.26

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Properties

Related Categories Apoptosis and Cell Cycle, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience,
Quality Level   100
assay   ≥98% (HPLC)
form   powder
color   yellow to orange
solubility   DMSO: 15 mg/mL, clear
storage temp.   2-8°C
SMILES string   NC1=CC=C(/C=C2SC(NC\2=O)=N)C=C1

Description

Biochem/physiol Actions

PFM39 is a potent cell-permeable Mirin analog that selectively inhibits MRE11 exo-, but not endo-, nuclease activity. PFM39 targets MRE11 in a fashion similar to Mirin, but distinct from that of PFM01 to allow a blockage of dsDNA phosphate backbone rotation and selective inhibition against MRE11 exo-, but not endo-, nuclease activity. FM39 potently impairs G2-phase double-strand break (DSB) repair in 1BR3-hTERT fibrolasts following ionizing irradiation (IR).

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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