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SML1851 Sigma-Aldrich

RI(dl)-2

≥98% (HPLC)

Synonym: N-Ethyl-4-(pyrrolo[1,2-a]quinoxalin-4-yl)aniline

  • CAS Number 1902146-75-1 (free base)

  • Empirical Formula (Hill Notation) C19H17N3 · xC2HF3O2

  • Molecular Weight 287.36 (free base basis)

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Properties

Related Categories Apoptosis and Cell Cycle, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience,
Quality Level   100
assay   ≥98% (HPLC)
form   powder
color   , light orange to dark red
solubility   DMSO: 20 mg/mL, clear
storage temp.   2-8°C
SMILES string   CCNC1=CC=C(C2=NC3=C(N4C2=CC=C4)C=CC=C3)C=C1.FC(F)(C(O)=O)F

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

RI(dl)-2 is a cell-permeable pyrroloquinoxaline derivative that selectively inhibits Rad51-mediated D-loop formation (IC50 = 11.1 μM) without affecting its ssDNA-binding activity (IC50 >100 μM). RI(dl)-2 is shown to inhibit DSBs-induced cellular homologous recombination (HR) activity (IC50 = 3.0 μM by HEK293-based DR-GFP reporter assay) by stabilizing nucleoprotein filaments in a nonfunctional state without affecting DNA damage-induced RAD51 nuclear loci formation or stimulating single-strand annealing (SSA) activity.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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