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SML1935 Sigma-Aldrich

Nimorazole

≥98% (HPLC)

Synonym: 4-(2-(5-Nitro-1H-imidazol-1-yl)ethyl)morpholine, K 1900, K-1900, K1900, NSC 107524, NSC-107524, NSC107524

  • CAS Number 6506-37-2

  • Empirical Formula (Hill Notation) C9H14N4O3

  • Molecular Weight 226.23

  •  EC Number 229-394-4

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, N
assay   ≥98% (HPLC)
form   powder
color   white to beige
solubility   DMSO: 30 mg/mL, clear
storage temp.   2-8°C

Description

Biochem/physiol Actions

Nimorazole is a nitroimidazole-based hypoxic cell-radiation sensitizer with less toxicity than etanidazole or misonidazole. Under low oxygen (hypoxic) condition, reductive activation of its 5-nitroimidazole moiety leads to enhanced adduct formation with reduced glutathione, which form the basis of cancer/tumour-selective radiation sensitization. Nimorazole is also a known anti-infective agent against trichomoniasis, an infectious disease caused by the protozoan parasite Trichomonas vaginalis.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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