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SML1962 Sigma-Aldrich

IWP-O1

≥98% (HPLC)

Synonym: 5-Phenyl-N-(5-phenylpyridin-2-yl)-4-(pyridin-4-yl)-1H-1,2,3-triazol-1-acetamide, IWP-01, IWP-O1

  • CAS Number 2074607-48-8

  • Empirical Formula (Hill Notation) C26H20N6O

  • Molecular Weight 432.48

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, I
assay   ≥98% (HPLC)
form   powder
color   white to beige
solubility   DMSO: 25 mg/mL, clear
storage temp.   2-8°C

Description

Biochem/physiol Actions

IWP-O1 is an inhibitor of Porcupine (Porcn), an acyl (palmitoyl) transferase essential for secretion of Wnt proteins and involved in both embryonic development and tumor progression. IWP-O1 has good metabolic stability and is extremely potent, exhibiting an EC50 value of 80 pM in a cultured cell reporter assay of Wnt signaling.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport

Documents

Certificate of Analysis

Protocols & Articles
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