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SML1996 Sigma-Aldrich

S3226

≥98% (HPLC)

Synonym: 3,3′-(4-Methyl-1,2-phenylene)bis[N-(aminoiminomethyl)-2-methyl-2-propenamide] dihydrochloride, S 3226, S-3226

  • Empirical Formula (Hill Notation) C17H22N6O2 · 2HCl

  • Molecular Weight 415.32

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, S
assay   ≥98% (HPLC)
form   powder
color   white to beige
solubility   H2O: 2 mg/mL, clear
shipped in   ambient
storage temp.   2-8°C
SMILES string   O=C(N=C(N)N)C(C)=CC1=CC(C)=CC=C1C=C(C)C(NC(N)=N)=O.[H]Cl.[H]Cl

Description

Biochem/physiol Actions

S3226 is a potent and selective NHE3 (NHE-3) inhibitor (IC50 = 20 nM/human NHE3, 3.6 μM/human NHE1, 80 μM/rabbit NHE2) for studying NHE3 physiological as well as pathophysiological roles in kidney and gastrointestinal disorders in vitro and in animal models in vivo.

S3226 is also known as {3-[2-(3-guanidino-2-methyl-3-oxo-propenyl)-5-methyl-phenyl]-N-isopropylidene-2-methyl-acrylamide dihydro-chloride}. S3226 is used to explore the physiological and pathophysiological functions of sodium-hydrogen exchanger 3 (NHE3) in animal models. It is a bismethacryloyl guanidine derivative.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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