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SML2070 Sigma-Aldrich

23-Hydroxybetulinic acid

≥98% (HPLC)

Synonym: (3β,4α)-3,23-Dihydroxylup-20(29)-en-28-oic acid, 3β,23-Dihydroxylup-20(29)-en-28-oic acid, 3aH-Cyclopenta[a]chrysene, lup-20(29)-en-28-oic acid deriv., Anemosapogenin

  • CAS Number 85999-40-2

  • Empirical Formula (Hill Notation) C30H48O4

  • Molecular Weight 472.70

  •  MDL number MFCD28126999

  •  NACRES NA.77

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Properties

Related Categories 0-9, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology
assay   ≥98% (HPLC)
form   powder
storage condition   under inert gas
color   white to beige
solubility   DMSO: 2 mg/mL, clear
storage temp.   −20°C
SMILES string   O[C@H]1CC[C@@]2(C)[C@](CC[C@]3(C)[C@]2([H])CC[C@@]4([H])[C@@]3(C)CC[C@]5(C(O)=O)[C@]4([H])[C@H](C(C)=C)CC5)([H])[C@]1(C)CO

Description

Biochem/physiol Actions

23-Hydroxybetulinic acid is a cytotoxic agent from rizoma of Pulsatilla chinensis (Bunge) Regel. Anticancer activity of 23-Hydroxybetulinic acid is associated with depolarizations of the mitochondrial membrane potential and subsequent cell apoptosis. Additionally it induces autophagic cell death in HL-60 cells via the up regulation of Beclin-1.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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