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SML2152 Sigma-Aldrich

10Panx1 trifluoroacetate salt

≥98% (HPLC)

Synonym: 10Panx trifluoroacetate salt, Trp-Arg-Gln-Ala-Ala-Phe-Val-Asp-Ser-Tyr trifluoroacetate salt, WRQAAFVDSY trifluoroacetate salt

  • CAS Number 955091-53-9 (free base)

  • Empirical Formula (Hill Notation) C58H79N15O16 · xC2HF3O2

  • Molecular Weight 1242.34 (free base basis)

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Properties

assay   ≥98% (HPLC)
form   lyophilized powder
color   white to beige
shipped in   wet ice
storage temp.   −20°C

Description

Biochem/physiol Actions

The pannexin-1 (panx1) extracellular sequence-derived 10panx1 functions as a reversible panx1 channel blocker (IC50 = 52 μM; human panx1-overexpressing HEK cells) that effectively inhibits ATP-induced dye-uptake in panx1 HEK cells co-expressing rat or human P2X7R (IC50 = 93 μM), as well as in murine J774 and human alveolar macrophages (Effective conc. 100-200 μM). 10panx1 (100 μM) is shown to protect rat hippocampal neurons against death induction upon NMDAR overactivation by excitotoxic concentrations of NMDA (100 μM) in cultures and ameliorate withdrawal symptoms among morphine-treated rats in vivo (10 μg/rat via intrathecal injection).

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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