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SML2160 Sigma-Aldrich

R-568 hydrochloride

≥95% (HPLC)

Synonym: 2-chloro-N-[(1R)-1-(3-methoxyphenyl)ethyl]-benzenepropanamine hydrochloride (1:1), KRN 568 hydrochloride, NPS-R 568 hydrochloride, Norcalcin hydrochloride, R 568 hydrochloride, Tecalcet hydrochloride

  • CAS Number 177172-49-5

  • Empirical Formula (Hill Notation) C18H22ClNO · HCl

  • Molecular Weight 340.29

  •  MDL number MFCD16038895

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, R
assay   ≥95% (HPLC)
form   powder
optical activity   [α]/D +35 to +40°, c = 0.5 in chloroform-d
storage condition   desiccated
color   white to beige
solubility   DMSO: 2 mg/mL, clear (warmed)
storage temp.   2-8°C

Description

Biochem/physiol Actions

R-568 is a positive allosteric modulator of the calcium-sensing receptor (CaSR), increasing the sensitivity to activation by extracellular Ca2+. In rats, orally administered R-568 decreases plasma levels of PTH and Ca2+ and, at higher doses, increases plasma levels of calcitonin.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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