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SRP6179 Sigma-Aldrich

Procathepsin K human

recombinant, expressed in E. coli, ≥95% (SDS-PAGE)

Synonym: CTSK, CTSO3, CTSO

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Properties

biological source   human
recombinant   expressed in E. coli
assay   ≥95% (SDS-PAGE)
form   liquid
mol wt   35.9 kDa
packaging   pkg of 1 mg
  pkg of 50 μg
concentration   1 mg/mL
UniProt accession no.   P43235
shipped in   dry ice
storage temp.   −70°C
Gene Information   human ... CATK(1513)

Description

General description

Cathepsin K, a member of the papain cysteine proteinase family is the predominant proteinase responsible for the resorption of the bone matrix. Cathepsin cleaves proteins such as collagen type I, collagen type II and osteonectin, thereby playing a role in bone remodeling and resorption in osteoporosis, osteolytic bone metastasis and rheumatoid arthritis (Bromme and Okamoto, 1995; Drake, F. et al 1996; Bossard et al, 1996). Cathepsin K is synthesized as an inactive proenzyme (35.1 kDa) that is converted to its mature active form (23.6 kDa) by proteolytic cleavage of its 99-amino-acid propeptide domain. The in-vitro processing of procathepsin K to mature cathepsin K is autocatalytic.

Physical form

1 mg/mL solution in 25 mM Na2HPO4 and 500 mM NaCl (pH 7.0).

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport

Documents

Certificate of Analysis (COA)

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