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  • SRP6282 - Nicotinamide N-Methyltransferase (hNNMT) human

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SRP6282 Sigma-Aldrich

Nicotinamide N-Methyltransferase (hNNMT) human

recombinant, expressed in E. coli, ≥98% (SDS-PAGE)

Synonym: NNMT

  •  NACRES NA.32

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Properties

biological source   human
recombinant   expressed in E. coli
assay   ≥98% (SDS-PAGE)
form   liquid
mol wt   31.7 kDa (263 aa + NT 6xHis-tag)
packaging   pkg of 1 mg
  pkg of 100 μg
  pkg of 20 μg
concentration   3.42 mg/mL
UniProt accession no.   P40261
shipped in   dry ice
storage temp.   −70°C
Gene Information   human ... NNMT(4837)

Description

General description

N-methylation is one method by which drug and other xenobiotic compounds are metabolized by the liver. NNMT is an important cytosolic methyltransferase catalyzing the N-methylation of nicotinamide, pyridines and structural analogs, playing a crucial role in the biotransformation and detoxification of many xenobiotic compounds. In the N-methylation process, NNMT uses S-adenosyl methionine as the methyl donor and nicotinamide as methyl acceptor. NNMT is mostly expressed in the liver, and a lower expression is seen in the kidney, lung, skeletal muscle, placenta and heart. It may also play an important role in regulating biological processes related to N-methyl nicotinamide such as anti-inflammatory, anti-thrombotic, vasoprotective, and gastroprotective properties. Increased NNMT activity was reported in many kinds of tumors. NNMT is a potential biomarker and therapeutic target in caner diagnosis and treatment. NNMT serum levels have significance in the premature detection and in the management of patients with colorectal cancer. The recombinant protein includes hNNMT with N-terminal His-tag.

Physical form

3.42 mg/mL solution in 25 mM Tris (pH8.0) buffer containing 20% glycerol.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport

Documents

Certificate of Analysis (COA)

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