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SRP6295 Sigma-Aldrich

IL-1 Alpha human

recombinant, expressed in HEK 293 cells, ≥97% (SDS-PAGE)

Synonym: IL-1α, IL-1A, IL1 ALPHA, IL1-ALPHA, IL1, IL1A, IL1F1, Interleukin-1 alpha, Interleukin

  •  NACRES NA.32

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Properties

Related Categories Cell Culture, Growth Factors and Cytokines, Interleukin-1, Interleukins (IL), Reagents and Supplements More...
biological source   human
recombinant   expressed in HEK 293 cells
assay   ≥97% (SDS-PAGE)
form   lyophilized powder
mol wt   calculated mol wt 18.0 kDa (no tag)
  observed mol wt 22 kDa by SDS-PAGE (DTT-reduced.)
packaging   pkg of 10 μg
UniProt accession no.   P01583
shipped in   wet ice
storage temp.   −20°C
Gene Information   human ... IL-1a(3552)

Description

General description

Interleukin-1α (IL1α) is also known as IL-1A, IL1, IL1-α, IL1F1, and is a cytokine of the interleukin-1 family. IL-1α is constitutively produced by epithelial cells. It is found in substantial amounts in normal human epidermis and is distributed in a 1:1 ratio between living epidermal cells and stratum corneum. The gene encoding this protein is localized on human chromosome 2.

Biochem/physiol Actions

Interleukin-1α (IL1α) possesses a wide spectrum of metabolic, physiological, hematopoietic activities, and plays one of the central roles in the regulation of the immune responses. It binds to the interleukin-1 receptor. The constitutive production of large amounts of IL-1α precursor by healthy epidermal keratinocytes interfere with the important role of IL-1α in immune responses, assuming skin as a barrier, which prevents the entry of pathogenic microorganisms into the body. In vitro, IL-1α possesses biological effect on cells in the picomolar to femtomolar range. In vivo, shortly after an onset of an infection into organism, IL-1α activates a set of immune system response processes.

Physical form

Lyophilized from 0.22 μm filtered solution in in PBS, pH 7.4. Generally 5-8% Mannitol or trehalose is added as a protectant before lyophilization.

Reconstitution

Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 μg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport

Documents

Certificate of Analysis (COA)

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Protocols & Articles

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Peer-Reviewed Papers
15

References

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