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SRP6318 Sigma-Aldrich

Kininogen,HMW from human plasma

≥95% (SDS-PAGE)

Synonym: Alpha-2-thiol proteinase inhibitor, BDK, Fitzgerald factor, High molecular weight Kininogen, KNG, Kininogen-1 heavy chain, Kininogen-1 light chain, Low molecular weight growth-promoting, Lysyl-bradykinin, T-kinin Bradykinin, Williams-Fitzgerald-Flaujeac factor

  •  NACRES NA.32

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Properties

biological source   human plasma
assay   ≥95% (SDS-PAGE)
form   frozen liquid
mol wt   120 kDa
packaging   pkg of 100 μg
UniProt accession no.   P01042
shipped in   dry ice
storage temp.   −70°C
Gene Information   human ... KNG1(3827)

Description

General description

HMW kininogen, synthesized by hepatocytes, is a multifunctional protein. It is the precursor protein of bradykinin. In addition it is a cofactor in the activation of factor XI, XII, and prekallikrein and a major extra-cellular cysteine proteinase inhibitor. Kininogens inhibit systemic proteases which are thought to have a part in various diseases such as cancer, muscular dystrophy and joint disease.

Physical form

Frozen in 10 mM Na acetate, pH 5.5 with 250 mM NaCI.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
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