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SRP6321 Sigma-Aldrich

BMP-3b human

recombinant, expressed in E. coli, ≥95% (SDS-PAGE)

Synonym: BIP, BMP-3b, BMP3B, Growth differentiation factor 10

  •  NACRES NA.32

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Properties

Related Categories Cell Culture, Growth Factors and Cytokines, Reagents and Supplements, Recombinant Bone Morphogenetic Proteins (BMP), Transforming Growth Factors More...
biological source   human
recombinant   expressed in E. coli
assay   ≥95% (SDS-PAGE)
form   liquid
mol wt   12.5 kDa (111 aa, 369-478 aa)
packaging   pkg of 100 μg
concentration   1 mg/mL
UniProt accession no.   P55107
shipped in   dry ice
storage temp.   −70°C
Gene Information   human ... GDF10(2662)

Description

General description

GDF10 (growth differentiation factor 10) is a member of the bone morphogenetic protein (BMP) family and the TGF-β (transforming growth factor β) superfamily. It is expressed in femur, brain, lung, skeletal, muscle, pancreas and testis. Recombinant GDF10 protein was expressed in Escherichia coli and purified by using conventional chromatography techniques.

Biochem/physiol Actions

In rats, ectopic expression of GDF10 (growth differentiation factor 10) enhances osteoblast differentiation and also helps in bone formation. It plays a role in head formation in Xenopus embryos. After stroke, it is involved in axonal sprouting and functional recovery. The GDF10 gene is downregulated in lung cancer, mammary tumor, oral cancer and malignant mesothelioma.

Physical form

1 mg/mL in 10 mM sodium citrate (pH 3.5) containing 10% glycerol.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

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Peer-Reviewed Papers
15

References

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