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SRP6322 Sigma-Aldrich

BMP8B human

recombinant, expressed in E. coli, ≥90% (SDS-PAGE)

Synonym: BMP8, Bone morphogenetic protein 8B, OP2

  •  NACRES NA.32

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Properties

Related Categories Cell Culture, Growth Factors and Cytokines, Reagents and Supplements, Recombinant Bone Morphogenetic Proteins (BMP), Transforming Growth Factors More...
biological source   human
recombinant   expressed in E. coli
assay   ≥90% (SDS-PAGE)
form   liquid
mol wt   18.1 kDa (162 aa, 264-402 aa + His tag)
packaging   pkg of 100 μg
concentration   1 mg/mL
UniProt accession no.   P34820
shipped in   dry ice
storage temp.   −70°C
Gene Information   human ... BMP8B(656)

Description

General description

The BMP8B (bone morphogenetic protein 8b) gene is mapped to human chromosome 1p34.2. It is also expressed in testis germ cell.

The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-β (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extra skeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development. In addition, the fact that this BMP is closely related to BMP5 and BMP7 has led to speculation of possible bone inductive activity. Recombinant human BMP8B protein, fused to His-tag at N-terminus, was expressed in E.coli.

Biochem/physiol Actions

The BMP8B (bone morphogenetic protein 8b) gene expression prevents cancer cell proliferation and activates cell death. Decreased gene expression is observed in pancreatic cancer. BMP8B mediates the process of placentation, by regulating cell division, differentiation and survival. It prevents glucocorticoid-induced bone cell death.

Physical form

1 mg/mL in 20 mM Tris-HCl buffer (pH 8.0) containing 0.4 M Urea and 10% glycerol.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport

Documents

Certificate of Analysis (COA)

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Protocols & Articles

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Peer-Reviewed Papers
15

References

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