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SRP6323 Sigma-Aldrich

Pentraxin 3 human

recombinant, expressed in E. coli, ≥90% (SDS-PAGE)

Synonym: PTX3, TNFAIP5, TSG-14

  •  NACRES NA.32

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Properties

biological source   human
recombinant   expressed in E. coli
assay   ≥90% (SDS-PAGE)
form   liquid
mol wt   44.4 kDa (401 aa, 18-381 aa + His Tag)
packaging   pkg of 100 μg
concentration   1 mg/mL
impurities   <1 EU/μg endotoxin (LAL test)
UniProt accession no.   P26022
shipped in   dry ice
storage temp.   −70°C
Gene Information   human ... PTX3(5806)

Description

General description

Pentraxin 3 (PTX3) or tumor necrosis factor (TNF)-stimulated gene is the prototypic member of the long pentraxin family sharing the C-terminal domain with short pentraxins and containing a unique N-terminal domain. The gene encoding this protein is localized on human chromosome 3q25.32 and consists of 3 exons. Recombinant human Pentraxin 3 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.

Biochem/physiol Actions

Pentraxin 3 (PTX3) is an acute phase protein produced and released at inflammatory sites by diverse cell types including monocytes/macrophages, endothelial cells, vascular smooth muscle cells, fibroblasts, and adipocytes. It plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components and female fertility. PTX3 particularly functions as a soluble pathogen recognition receptor and confers resistance against pathogens. Studies indicate that the protein removes apoptotic cells during immune responses. It associates with complement factor H, which is a complement regulator protein.

Physical form

1 mg/mL in 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, and 1 mM DTT.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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