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SRP6331 Sigma-Aldrich

CD5 human

recombinant, expressed in E. coli, ≥80% (SDS-PAGE)

Synonym: LEU1, T-cell surface glycoprotein CD5, T1

  •  NACRES NA.32

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Properties

Related Categories CD1 to CD48, Cell Biology, Cell Signaling and Neuroscience, Cluster of Differentiation (CD) Proteins, Cytokines and Growth Factors,
biological source   human
recombinant   expressed in E. coli
assay   ≥80% (SDS-PAGE)
form   liquid
mol wt   41 kDa (371 aa, 25-372 aa + His tag)
packaging   pkg of 50 μg
concentration   1 mg/mL
impurities   <1 EU/μg endotoxin (LAL test)
UniProt accession no.   P06127
shipped in   dry ice
storage temp.   −70°C
Gene Information   human ... CD5(921)

Description

General description

CD5 (cluster of differentiation 5) is a lymphocyte surface receptor. It is expressed by all T cells and the B1a subset of mature B cells (participating in the generation of low-affinity polyreactive antibodies). The CD5 gene is mapped to human chromosome 11q12.
Recombinant human CD5 protein, fused to His-tag at N-terminus, was expressed in Escherichia coli.

Biochem/physiol Actions

CD5 (cluster of differentiation 5) is required for fine tuning of TCR (T-cell receptor) signaling. It also controls activation-mediated T cell death and recognizes pathogen-associated molecular patterns. In T and B1 cells, CD5 negatively regulates the signaling by clonotypic antigen-specific receptor. CD5 is present in patients with rheumatoid arthritis, systemic lupus erythematosus, Sjögren syndrome, Grave′s Basedow thyroiditis and type 1 diabetes mellitus. In infants, high levels of CD5+ cells suggest the risk of development of allergic disease. The gene is also associated with peripheral T-cell lymphoma and mature B-cell neoplasms (mainly chronic lymphocytic leukemia and mantle cell lymphoma).

Physical form

1 mg/mL in 20 mM Tris-HCl buffer (pH 8.0) containing 0.4 M Urea and 10% glycerol.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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