SRP6331 Sigma-Aldrich

CD5 human

recombinant, expressed in E. coli, ≥80% (SDS-PAGE)

Synonym: LEU1, T-cell surface glycoprotein CD5, T1

  •  NACRES NA.32



Related Categories CD1 to CD48, Cell Biology, Cell Signaling and Neuroscience, Cluster of Differentiation (CD) Proteins, Cytokines and Growth Factors,
biological source   human
recombinant   expressed in E. coli
assay   ≥80% (SDS-PAGE)
form   liquid
mol wt   41 kDa (371 aa, 25-372 aa + His tag)
packaging   pkg of 50 μg
concentration   1 mg/mL
impurities   <1 EU/μg endotoxin (LAL test)
UniProt accession no.   P06127
shipped in   dry ice
storage temp.   −70°C
Gene Information   human ... CD5(921)


General description

CD5 (cluster of differentiation 5) is a lymphocyte surface receptor. It is expressed by all T cells and the B1a subset of mature B cells (participating in the generation of low-affinity polyreactive antibodies). The CD5 gene is mapped to human chromosome 11q12.
Recombinant human CD5 protein, fused to His-tag at N-terminus, was expressed in Escherichia coli.

Biochem/physiol Actions

CD5 (cluster of differentiation 5) is required for fine tuning of TCR (T-cell receptor) signaling. It also controls activation-mediated T cell death and recognizes pathogen-associated molecular patterns. In T and B1 cells, CD5 negatively regulates the signaling by clonotypic antigen-specific receptor. CD5 is present in patients with rheumatoid arthritis, systemic lupus erythematosus, Sjögren syndrome, Grave′s Basedow thyroiditis and type 1 diabetes mellitus. In infants, high levels of CD5+ cells suggest the risk of development of allergic disease. The gene is also associated with peripheral T-cell lymphoma and mature B-cell neoplasms (mainly chronic lymphocytic leukemia and mantle cell lymphoma).

Physical form

1 mg/mL in 20 mM Tris-HCl buffer (pH 8.0) containing 0.4 M Urea and 10% glycerol.

Safety & Documentation

Safety Information

NONH for all modes of transport
WGK Germany 
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable


Certificate of Analysis (COA)

Please Enter a Lot Number
Protocols & Articles
Peer-Reviewed Papers


Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?