SRP6333 Sigma-Aldrich

CD74 human

recombinant, expressed in E. coli, ≥90% (SDS-PAGE)

Synonym: DHLAG, HLA class II histocompatibility antigen gamma chain isoform b, HLADG, Ia-GAMMA

  •  NACRES NA.32



Related Categories CD55 to CD155, Cell Biology, Cell Signaling and Neuroscience, Cluster of Differentiation (CD) Proteins, Cytokines and Growth Factors,
biological source   human
recombinant   expressed in E. coli
assay   ≥90% (SDS-PAGE)
form   liquid
mol wt   20.6 kDa (183 aa, 73-232 aa + His tag)
packaging   pkg of 100 μg
concentration   0.5 mg/mL
impurities   <1 EU/μg endotoxin (LAL test)
UniProt accession no.   P04233
shipped in   dry ice
storage temp.   −70°C
Gene Information   human ... CD74(972)


General description

HLA class II histocompatibility antigen gamma chain isoform b, also known as CD74, is a transmembrane protein which, on antigen presenting cells, is the invariant chain that chaperones MHC class II dimers from the endoplasmic reticulum to the cell surface. CD74 is expressed by cells of both T lymphocyte and B lymphocyte lineages. It is upregulated in several cancers and is also expressed by nonimmune cells during inflammation. Recombinant human CD74 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

Physical form

0.5 mg/mL in 20 mM Tris-HCl buffer (pH 8.0) containing 0.1 M NaCl, 1 mM DTT and 30% glycerol.

Safety & Documentation

Safety Information

NONH for all modes of transport


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