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SRP6370 Sigma

Aldolase A human

recombinant, expressed in E. coli, ≥95% (SDS-PAGE)

Synonym: ALDA, ALDOA, Fructose bisphosphate Aldolase A, GSD12

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Properties

recombinant   expressed in E. coli
assay   ≥95% (SDS-PAGE)
form   liquid
mol wt   mol wt 41.5 kDa (384 aa, 1-364 aa + His Tag)
concentration   1 mg/mL
UniProt accession no.   P04075
shipped in   dry ice
storage temp.   −70°C
Gene Information   human ... ALDOA(226)

Description

Physical form

1 mg/mL in 20 mM Tris-HCl buffer (pH 8.0) containing 100 mM NaCl and 10% glycerol.

Biochem/physiol Actions

In glycolysis, aldolase A (ALDOA) catalyzes the reversible reaction of fructose-1,6-bisphosphate to glyceraldehydes-3-phosphate and dihydroxyacetone phosphate. It is involved in a wide range of cellular functions such as maintenance of striated muscle contraction, cell shape and mobility, actin filament organization and ATP biosynthetic process. High expression level of ALDOA is reported in various forms of malignant cancers, including human lung squamous, renal cell and hepatocellular carcinomas. ALDOA deficiency causes myopathy and hemolytic anemia.

General description

Aldolase A (ALDOA) is a ubiquitous glycolytic enzyme expressed in developing embryos and in adult muscles. The gene encoding it is localized on human chromosome 16p11.2. Recombinant human Aldolase A, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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