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SRP6412 Sigma-Aldrich

BRD2 (1-455) his tag human

recombinant, expressed in E. coli, ≥90% (SDS-PAGE)

Synonym: Bromodomain containing 4, D6S113E, FSH, FSRG1, NAT, RING3, RNF3

  •  NACRES NA.32

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Properties

biological source   human
recombinant   expressed in E. coli
assay   ≥90% (SDS-PAGE)
form   liquid
mol wt   52.8 kDa (478 aa, 1-455 aa + His Tag)
packaging   pkg of 100 μg
concentration   1 mg/mL
NCBI accession no.   NM_005104
UniProt accession no.   P25440
shipped in   dry ice
storage temp.   −70°C
Gene Information   human ... BRD2(6046)

Description

General description

The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. A bromodomain is a protein domain that recognizes acetylated lysine residues such as those on the N-terminal tails of histones. This recognition is often a prerequisite for protein-histone association and chromatin remodeling. These domains function in the linking of protein complexes to acetylated nucleosomes, thereby controlling chromatin structure and gene expression. Thus, bromodomains serve as “readers” of histone acetylation marks regulating the transcription of target promoters. The BET family of proteins, defined by tandem Bromodomains and an Extra Terminal domain, include BRD2, BRD3, BRD4, and BRDT. The BET proteins play a key role in many cellular processes, including inflammatory gene expression, mitosis, and viral/host interactions. The isolated individual or tandem bromodomains of BRD2 and BRD4 have been shown to bind acetylated histone tails, serving to couple histone acetylation marks to the transcriptional regulation of target promoters. Small molecule inhibitors of these interactions hold promise as useful therapeutics for human disease. This protein can be used for the study of bromodomain binding assays, screening inhibitors, and selectivity profiling.

Physical form

1 mg/mL in Phosphate buffer saline (pH 7.4) containing 10% glycerol and 1 mM DTT.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport

Documents

Certificate of Analysis (COA)

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