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SRP6426 Sigma-Aldrich

E-Cadherin/ECAD/Cadherin-1/CD324 Protein human

recombinant, expressed in HEK 293 cells, ≥90% (SDS-PAGE)

Synonym: Arc-1, CDH1, LCAM, UVO

  •  NACRES NA.32

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Properties

biological source   human
recombinant   expressed in HEK 293 cells
sterility   sterile
assay   ≥90% (SDS-PAGE)
form   lyophilized
mol wt   calculated mol wt 67 kDa
  observed mol wt 67 kDa (DTT-reduced. Protein migrates due to glycosylation. Gln 23 is the predicted N-terminal.)
packaging   pkg of 25 μg
conjugate   6-His tagged (C-terminus)
UniProt accession no.   P12830
shipped in   wet ice
storage temp.   −20°C
Gene Information   human ... CDH1(999)

Description

General description

Cadherin-1 (CDH1) is a transmembrane protein, which is mainly involved in cell adhesion in normal epithelia. The associated gene is mapped to human chromosome 16q22.1.

Biochem/physiol Actions

Cadherin-1 (CDH1) stabilizes the cell adhesion in normal cells and also helps in signaling via association with β catenin. Mutations in the CDH1 gene are linked with oral clefts in the Thai population. CDH1 works as a tumor suppressor in various cancers. Low expression of CDH1 increases cellular invasive and metastatic potential. For instance, low expression of this gene is associated with poor survival of patients with esophageal cancer.

Physical form

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally Mannitol or Trehalose is added as protectants before lyophilization.

Reconstitution

Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 μg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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