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SRP6431 Sigma-Aldrich

ICOSLG/B7-H2/CD275 human

recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE)

Synonym: B7H2, B7RP-1, B7RP1, GL50, ICOS ligand, ICOS-L, ICOSL, LICOS

  •  NACRES NA.32

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Properties

Related Categories CD160 to CD340, Cell Biology, Cell Signaling and Neuroscience, Cluster of Differentiation (CD) Proteins, Cytokines and Growth Factors,
biological source   human
recombinant   expressed in HEK 293 cells
assay   ≥95% (SDS-PAGE)
form   lyophilized
potency   3.2-400 ng/mL
mol wt   calculated mol wt 27.5 kDa
  observed mol wt 45-50 kDa (DTT-reduced. Protein migrates due to glycosylation. Asp 19 is the predicted N-terminal.)
packaging   pkg of 20 and 100 μg
impurities   <1 EU/μg
conjugate   6-His tagged (C-terminus)
UniProt accession no.   O75144
shipped in   wet ice
storage temp.   −20°C
Gene Information   human ... ICOSLG(23308)

Description

General description

ICOS ligand (ICOSLG) is also known as B7 homolog 2 (B7-H2), B7-related protein 1 (B7RP-1) and CD antigen CD275, which belongs to the immunoglobulin superfamily and BTN/MOG family. ICOSLG contains one Ig-like C2-type (immunoglobulin-like) domain and one Ig-like V-type (immunoglobulin-like) domain. Isoform 1 is widely expressed, while isoform 2 is detected only in lymph nodes, leukocytes and spleen. B7-H2 is ligand for the T-cell-specific cell surface receptor ICOS. B7-H2 acts as a costimulatory signal for T-cell proliferation and cytokine secretion and induces also B-cell proliferation and differentiation into plasma cells. B7-H2 could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function.

Physical form

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally Mannitol or Trehalose is added as protectants before lyophilization.

Reconstitution

Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 μg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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