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SRP6449 Sigma-Aldrich

LIFR/CD118 human

recombinant, expressed in HEK 293 cells, ≥96% (SDS-PAGE)

Synonym: Cluster of Differentiation 118, FLJ98106, FLJ99923, LIF-R, Leukemia inhibitory factor receptor, SJS2, STWS, SWS

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Properties

recombinant   expressed in HEK 293 cells
assay   ≥96% (SDS-PAGE)
form   lyophilized
mol wt   monomer calculated mol wt 115.5 kDa (This protein is fused with the Fc region of human IgG1 at the CT.)
  observed mol wt 135-150 kDa by SDS-PAGE (reducing)
impurities   <1 EU/μg endotoxin (LAL test)
UniProt accession no.   P42702
shipped in   wet ice
storage temp.   −20°C
Gene Information   human ... LIFR(3977)

Description

General description

Leukemia inhibitory factor receptor also known as LIFR; CD118; FLJ98106; FLJ99923; LIF-R; SJS2; STWS; SWS, is the receptor for leukemia inhibitory factor (LIF). The leukemia inhibitory factor is a polyfunctional cytokine that affects the differentiation, survival, and proliferation of a wide variety of cells in the adult and the embryo. LIF action appears to be mediated through a high-affinity receptor complex composed of a low-affinity LIF binding chain (LIF receptor) and a high-affinity converter subunit, gp130. Both LIFR and gp130 are members of a family of cytokine receptors that includes components of the receptors for the majority of hematopoietic cytokines and for cytokines that affect other systems, including the ciliary neurotrophic factor, growth hormone and prolactin Defects in LIFR are the cause of Stueve-Wiedemann syndrome (SWS), a severe autosomal recessive condition and belongs to the group of the bent-bone dysplasias.

Physical form

Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally Mannitol or Trehalose is added as protectants before lyophilization.

Reconstitution

Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 μg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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