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SRP6517 Sigma-Aldrich

Alpha 2HS Glycoprotein from human plasma

≥90% (SDS-PAGE)

Synonym: Alpha-2-Z-globulin, Ba-alpha-2-glycoprotein, Fetuin-A

  •  NACRES NA.32

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Properties

biological source   human
assay   ≥90% (SDS-PAGE)
form   lyophilized
mol wt   49 kDa
packaging   pkg of 1 mg
UniProt accession no.   P02765
shipped in   wet ice
storage temp.   −20°C
Gene Information   human ... AHSG(197)

Description

General description

AHSG (α2-HS glycoprotein), or fetuin-A, is a predominant serum glycoprotein with a molecular weight of 64kDa, and is produced and secreted primarily by hepatic cells. It is highly present in the extracellular matrix (ECM) of the bone.

Biochem/physiol Actions

AHSG (α2-HS glycoprotein) is a multifunctional protein, and acts as an inhibitor of insulin receptor tyrosine kinase. It is involved in insulin resistance by promoting adipose tissue inflammation by functioning as a ligand for Toll-like receptor 4. Therefore, it is linked to the type 2 diabetes. This protein plays a crucial role in the prevention of extracellular calcification. This protein is a candidate plasma biomarker for early hypopharyngeal squamous cell carcinoma (HSCC) diagnosis. It is also a negative acute-phase protein, and its serum levels reduce drastically following surgeries, trauma, burns, and severe inflammation. Studies in Chinese populations show the serum levels of this protein is linked with fatty liver index (FLI), alanine aminotransferance (ALT), and aspartate aminotransferance (AST), which are early indicators of nonalcoholic fatty liver disease (NAFLD).

Physical form

Lyophilized from 20 mM Tris-HCl, pH 7.5, with 2 mM EDTA.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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