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SRP6530 Sigma-Aldrich

NMNAT1 human

recombinant, expressed in E. coli, ≥95% (SDS-PAGE)

Synonym: EC 2.7.7.1, NMN Adenylyltransferase 1, NaMN Adenylyltransferase 1, Nicotinamide Mononucleotide Adenylyl-transferase 1

  •  NACRES NA.32

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Properties

biological source   human
recombinant   expressed in E. coli
assay   ≥95% (SDS-PAGE)
form   liquid
mol wt   monomer ~333 kDa (Human full-length NMNAT1 aa 1-279 is fused at the N-terminus to a His-tag.)
packaging   pkg of 10 and 50 μg
concentration   1 mg/mL
UniProt accession no.   Q9HAN9
shipped in   wet ice
storage temp.   −20°C
Gene Information   human ... NMNAT1(64802)

Description

General description

This is the nuclear NMNAT isoform. It catalyzes the formation of NAD+ from nicotinamide mononucleotide (NMN) and ATP. It can also use the deamidated form of nicotinic acid mononucleotide (NAMN) as substrate with the same efficiency. It interacts with PARP-1/ARTD1. It protects against axonal degeneration following mechanical or toxic insults. It is widely expressed.

Physical form

1 mg/mL in 50 mM sodium phosphate, pH 8.0 containing 300 mM sodium chloride, 2 mM DTT and 10% glycerol.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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