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SRP6538 Sigma-Aldrich

Lipocalin-2/LCN2 from rat

recombinant, expressed in HEK 293 cells, ≥90% (SDS-PAGE)

Synonym: 24p3, MSFI, NGAL, Neutrophil Gelatinase-associated Lipocalin, Oncogene 24p3, Siderocalin

  •  NACRES NA.32

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Properties

biological source   rat
recombinant   expressed in HEK 293 cells
assay   ≥90% (SDS-PAGE)
form   liquid
mol wt   monomer ~250 kDa (Rat lipocalin-2 aa 1-198 is fused at the C-terminus to a FLAG0174-tag.)
packaging   pkg of 10 and 50 μg
impurities   <0.1 EU/μg endotoxin (LAL test)
UniProt accession no.   P30152
shipped in   wet ice
storage temp.   −20°C
Gene Information   rat ... LCN2(170496)

Description

General description

Lipocalin-2 (LCN2), also known as oncogene 24p3 or neutrophil gelatinase-associated lipocalin (NGAL), MSFI, The binding of lipocalin-2 to bacterial siderophores is important in the innate immune response to bacterial infection. Upon encountering invading bacteria the toll-like receptors on immune cells stimulate the synthesis and secretion of lipocalin-2. Secreted lipocalin-2 then limits bacterial growth by sequestering iron-containing siderophores. Lipocalin-2 also functions as a growth factor. LCN2 is strongly upregulated during inflammation and is upregulated by interleukin 1 (but not TNF α) in humans. There are indications that some forms of acne could be caused due to the gene not being transcribed, and that Isotretinoin corrects this. NFAT3 (NFATc4) NFAT by blocking the expression of LCN2 inhibits breast carcinoma cell motility. Recent studies have revealed that NGAL plays an important role in the physiopathology of chronic myeloid leukaemia (CML) mediated by BCR-ABL.

Physical form

0.2 μm-filtered solution in PBS.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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