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SRP6540 Sigma-Aldrich

PEDF from mouse

recombinant, expressed in E. coli, ≥95% (SDS-PAGE)

Synonym: Caspin, Pigment Epithelium-derived Factor, Serpin F1, Stromal Cell-derived Factor 3

  •  NACRES NA.32

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Properties

biological source   mouse
recombinant   expressed in E. coli
assay   ≥95% (SDS-PAGE)
form   lyophilized
mol wt   ~470 kDa (Mouse PEDF aa 20-417 is fused at the C-terminus to a FLAG0174-tag.)
packaging   pkg of 10 μg
impurities   <0.1 EU/μg endotoxin (LAL test)
UniProt accession no.   P97298
shipped in   wet ice
storage temp.   −20°C
Gene Information   mouse ... Serpinf1(20317)

Description

General description

Pigment epithelium-derived factor (PEDF) is a 47 kDa secreted glycoprotein that belongs to the non-inhibitory serpin family group. PEDF is widely expressed in adult and fetal tissues, including brain, spinal cord, plasma, bone, prostate, pancreas, heart and lung. PEDF acts as an angiogenesis inhibitor with neurotrophic, immunomodulation and antitumor properties. It functions as anti-angiogenic agent by counterbalancing the proangiogenic effect of VEGF. PEDF is one of the most abundant proteins released by adipocytes and induces insulin resistance in adipocytes and human skeletal muscle cells. Recently, it has been reported that PEDF is sufficient to maintain the self-renewal of pluripotent human embryonic stem cells.

Physical form

Lyophilized in PBS.

Reconstitution

Reconstitute with 100 μsterile distilled water.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport

Documents

Certificate of Analysis (COA)

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