EMAIL THIS PAGE TO A FRIEND
SRP6541 Sigma-Aldrich

FNDC4

recombinant, expressed in E. coli, ≥95% (SDS-PAGE)

Synonym: Fibronectin Type III Domain-containing Protein 4, Fibronectin Type III Repeat-containing Protein 1

  •  NACRES NA.32

Purchase

Properties

Related Categories Cell Biology, Cytokines Growth Factors and Hormones (Obesity), Obesity Research, Other Obesity Research Products
biological source   human
recombinant   expressed in E. coli
assay   ≥95% (SDS-PAGE)
form   lyophilized
mol wt   ~160 kDa (Extracellular domain, human aa 45-167 / mouse aa 41-163 is untagged. FNDC4 extracellular domain has 100% identity between human, mouse, rat, dog and monkey.)
packaging   pkg of 10 μg
impurities   <0.1 EU/μg endotoxin (LAL test)
UniProt accession no.   Q9H6D8
shipped in   wet ice
storage temp.   −20°C
Gene Information   human ... FNDC4(64838)

Description

General description

Irisin is a recently described exercise-induced hormone secreted by skeletal muscle in mice and humans. Irisin activates beige fat cells (beige cells have a gene expression pattern distinct from either white or brown fat and are preferentially sensitive to the polypeptide hormone Irisin). Irisin is cleaved from the type I membrane protein FNDC5 and improves systemic metabolism by increasing energy expenditure. FNDC4 is an ortholog of FNDC5 with 50% identity and 86% similarity compared to Irisin. FNDC4 as well as FNDC5 are extremely well conserved between species. The function of FNDC4 is unknown. The human FNDC4 gene is highly enriched in liver, brain tissue and adipocytes.

Physical form

Lyophilized in PBS.

Reconstitution

Reconstitute with 100 μL sterile distilled water.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

Please Enter a Lot Number
Protocols & Articles
Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?