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SRP6543 Sigma-Aldrich

Netrin-1 human

recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE)

Synonym: NTN1

  •  NACRES NA.32

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Properties

biological source   human
recombinant   expressed in HEK 293 cells
assay   ≥95% (SDS-PAGE)
form   lyophilized
mol wt   ~800 kDa (Human netrin-1 aa 25-604 is fused at the C-terminus to a FLAG0174-tag.)
packaging   pkg of 10 μg
impurities   <0.1 EU/μg endotoxin (LAL test)
UniProt accession no.   O95631
shipped in   wet ice
storage temp.   −20°C
Gene Information   human ... NTN1(9423)

Description

General description

Netrin-1 controls guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Netrin-1 is also Involved in tumorigenesis by regulating apoptosis.

Physical form

Lyophilized in PBS with trehalose and Brij 35.

Reconstitution

Reconstitute with 100 μsterile distilled water.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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