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SRP6550 Sigma

IL 17 A/F from mouse

recombinant, expressed in E. coli, ≥98% (SDS-PAGE)

Synonym: IL-17A, IL-17F, Interleukin 17 A/F, Interleukin 17A, Interleukin 17F

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Properties

Related Categories Cell Culture, Growth Factors and Cytokines, Interleukin-17, Interleukins (IL), Reagents and Supplements More...
biological source   mouse
recombinant   expressed in E. coli
assay   ≥98% (SDS-PAGE)
form   lyophilized
mol wt   mol wt 30.7 kDa
packaging   pkg of 1 mg
  pkg of 10 μg
  pkg of 50 μg
impurities   ≤1 EU/μg endotoxin (LAL test)
UniProt accession no.   Q62386/Q7TN17
shipped in   wet ice
storage temp.   −20°C
Gene Information   mouse ... IL17 A/F(16171)

Description

Reconstitution

Centrifuge vial before opening. When reconstituting the product, gently pipet and wash down the sides of the vial to ensure full recovery of the protein into solution. It is recommended to reconstitute the lyophilized product with sterile water at a concentration of 0.1 mg/mL, which can be further diluted into other aqueous solutions.

Physical form

Lyophilized without any additives.

General description

Interleukin-17AF (IL-17AF) is a member of the IL-17 family of proteins produced by a subset of T cells, called Th17, following stimulation with IL-23. Since IL-17AF is thought to signal through the IL-17R receptor, its biological function is similar to that of IL-17A in that it induces the production of a variety of chemokines, in addition to airway neutrophilia. In regard to these functions, IL-17AF has less activity than the IL-17A homodimer but, greater activity than the IL-17F homodimer. Human and rat IL-17AF both show activity on mouse cells. Recombinant mouse IL-17AF is a non-glycosylated, disulfide-linked heterodimer. It is comprised of one monomeric subunit each of IL-17A and IL-17F, having a total of 271 amino acids and a molecular weight of 30.7 kDa.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles

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