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SRP6558 Sigma-Aldrich

Cathepsin K Active from mouse

recombinant, expressed in E. coli, ≥90% (SDS-PAGE)

Synonym: CTSK, CTSO3, CTSO

  •  NACRES NA.32

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Properties

biological source   mouse
recombinant   expressed in E. coli
assay   ≥90% (SDS-PAGE)
form   liquid
mol wt   23.4 kDa (115-329 aa)
packaging   pkg of 5 μg
  pkg of 50 μg
concentration   0.5 mg/mL
UniProt accession no.   P55097
shipped in   dry ice
storage temp.   −70°C
Gene Information   mouse ... CTSK(13038)

Description

General description

Cathepsin K belongs to the peptidase C1 protein family and is a lysosomal cysteine protease. The associated gene is strongly expressed on osteoclasts and is also present in cardiomyocytes. Cathepsin K is the most abundant and main protease involved with osteoclastic activity.

Biochem/physiol Actions

Cathepsin K is responsible for collagenolytic and elastolytic activities. It can degrade type II collagen and thus participates in the degradation of articular cartilage. It also plays an important role in osteoarthritis and periodontitis. Removal of the cathepsin K activity provides protection against agents inducing metabolic stress in the heart. Absence of cathepsin K also protects from age-related decline in cardiac function by inhibition of caspase-associated and caspase-independent cell death.

Physical form

0.5 mg/mL solution in 25 mM Na2HPO4 and 500 mM NaCl (pH 7.0) with 50% glycerol.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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