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SRP6559 Sigma-Aldrich

Cathepsin K Active from rat

recombinant, expressed in E. coli, ≥90% (SDS-PAGE)

Synonym: CTSK, CTSO3, CTSO

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Properties

biological source   rat
recombinant   expressed in E. coli
assay   ≥90% (SDS-PAGE)
form   liquid
mol wt   23.5 kDa (115-329 aa)
packaging   pkg of 5 μg
  pkg of 50 μg
concentration   0.5 mg/mL
UniProt accession no.   O35186
shipped in   dry ice
storage temp.   −70°C
Gene Information   rat ... CTSK(21975)

Description

General description

Rat cathepsin K shares 88% identity with the human cathepsin K. It belongs to the papain superfamily and lysosomal protease family. The associated gene is strongly expressed in osteoclasts and osteoclastoma cells.

Biochem/physiol Actions

Cathepsin K is a cysteine proteinase which is mainly responsible for osteoclastic bone matrix solubilization. It exhibits elastolytic as well as collagenolytic activities.

Physical form

0.5 mg/mL solution in 25 mM Na2HPO4 and 500 mM NaCl (pH 7.0) with 50% glycerol.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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