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SRP6561 Sigma-Aldrich

Cathepsin K Active human

recombinant, expressed in E. coli, ≥90% (SDS-PAGE)

Synonym: CTSK, CTSO3, CTSO

  •  NACRES NA.32

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Properties

biological source   human
recombinant   expressed in E. coli
assay   ≥90% (SDS-PAGE)
form   liquid
mol wt   23.5 kDa (115-329 aa)
packaging   pkg of 5 μg
  pkg of 50 μg
concentration   0.5 mg/mL
UniProt accession no.   P43235
shipped in   dry ice
storage temp.   −70°C
Gene Information   human ... CTSK(1513)

Description

General description

Cathepsin K is expressed as procathepsin K, which is the inactive proenzyme of cathepsin K. Cathepsin K is a lysosomal cysteine protease and part of the papain cysteine protease family. It is expressed in osteoclasts. The gene encoding this protein is localized on human chromosome 1q21.

Biochem/physiol Actions

Cathepsin K has a role in bone resorption and remodeling. It has a triple helical collagen hydrolase activity. Mutations in the gene encoding this protein have been linked to pycnodysostosis.

Physical form

0.5 mg/mL solution in 25 mM Na2HPO4 and 500 mM NaCl (pH 7.0) with 50% glycerol.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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