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  • SRP6585 - Histone H2B (1-123) from Xanopus sp.

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SRP6585 Sigma-Aldrich

Histone H2B (1-123) from Xanopus sp.

recombinant, expressed in E. coli, ≥90% (SDS-PAGE)

Synonym: HIST1H2BA, Histone H2B type 1-A, TSH2B

  •  NACRES NA.32

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Properties

Related Categories Cell Biology, Cell Signaling and Neuroscience, Cytokines and Growth Factors, Cytokines, Growth Factors and Hormones, Histones,
biological source   Xenopus laevis
recombinant   expressed in E. coli
assay   ≥90% (SDS-PAGE)
form   lyophilized powder
mol wt   13.7 kDa (1-123 aa)
packaging   pkg of 100 and 250 μg
UniProt accession no.   Q96A08
shipped in   dry ice
storage temp.   −70°C
Gene Information   human ... H2B1A(255626)

Description

General description

H2A is a core component of nucleosome. A nucleosome is the basic repeating unit of chromatin in which 146 base pairs of DNA wrap twice around an octamer of histones. The octamer is composed of two of each histone H2A, H2B, H3, and H4. DNA accessibility is regulated via a complex set of post-translational modifications of these histones, also called histone code, and nucleosome remodeling. Histones H2A and H2B form a dimer. Histones H3 and H4 form a tetramer. The combination of two H2A/H2B dimers and one H3/H4 tetramer create the nucleosome core. Histone H2B undergoes many modifications which include acetylation, phosphorylation, ubiquitylation, sumoylation, and biotinylation that are important for regulation of gene transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.

Physical form

Lyophilized powder. Recommended buffer is 50 mM sodium phosphate, pH 7.2, containing 300 mM sodium chloride, 1 mM DTT, 1 mM EDTA and 20% glycerol.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
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