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T0397 Sigma-Aldrich

L-Thyroxine sodium salt pentahydrate

γ-irradiated, powder, BioXtra, suitable for cell culture

Synonym: 3-[4-(4-Hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]-L-alanine sodium salt, Sodium levothyroxine, T4

  • CAS Number 6106-07-6

  • Linear Formula HOC6H2I2OC6H2I2CH2CH(NH2)COONa · 5H2O

  • Molecular Weight 888.93

  •  Beilstein/REAXYS Number 5721845

  •  EC Number 200-221-4

  •  MDL number MFCD00149110

  •  PubChem Substance ID 24899887

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Properties

Related Categories Cell Biology, Cell Culture, Cell Signaling and Neuroscience, Cytokines, Growth Factors and Hormones, Hormones,
InChI Key   JMHCCAYJTTWMCX-QWPJCUCISA-M
sterility   γ-irradiated
product line   BioXtra
assay   ≥98%
form   powder
potency   5-50 ng/mL
mp   207-210 (dec.) (lit.)
solubility   cell culture medium: 0.1 mg/mL
  H2O: soluble
suitability   suitable for cell culture
storage temp.   −20°C
Gene Information   mouse ... Cnr2(12802)
rat ... Cnr1(25248)

Description

Biochem/physiol Actions

L-Thyroxine (T4) and triiodo-L-thyronine (T3) are iodine-containing hormones produced from thyroglobulin in the thyroid follicular cells. The stimulation of metabolic rate and regulation of growth and development by these hormones appear to be due to their effects on DNA transcription and thus, protein synthesis.

Physical form

powder-0 °C; stock-frozen in working aliquots, avoid repeated freeze/thaw, solution stable 2-8 °C, 30 days

Reconstitution

To prepare 20 μg/ml stock solution, add 50 ml sterile culture medium.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
YP2833760

Documents

Certificate of Analysis

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Certificate of Origin

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Protocols & Articles

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Peer-Reviewed Papers
15

References

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