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T2452 Sigma-Aldrich

Talsaclidine

≥98% (HPLC), oil

Synonym: (R)-3-(2-Propynyloxy)-1-Azabicyclo[2.2.2]octane, WAL 2014

  • CAS Number 147025-53-4

  • Empirical Formula (Hill Notation) C10H15NO

  • Molecular Weight 165.23

  •  PubChem Substance ID 329826707

  •  NACRES NA.77

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Neuroscience,
Quality Level   100
assay   ≥98% (HPLC)
form   oil
solubility   DMSO: >5 mg/mL
storage temp.   −20°C
SMILES string   C#CCO[C@H]1CN2CC[C@H]1CC2
InChI   1S/C10H15NO/c1-2-7-12-10-8-11-5-3-9(10)4-6-11/h1,9-10H,3-8H2/t10-/m0/s1
InChI key   XVFJONKUSLSKSW-JTQLQIEISA-N

Description

Packaging

10, 25 mg in glass bottle

Biochem/physiol Actions

Talsaclidine is a M1 selective muscarinic receptor agonist. Concentration-dependently, talsaclidine increases the release of APPs and dose-dependently. Talsaclidine decreases Aβ formation and decreases cerebrospinal fluid Aβ in AD patients.

Features and Benefits

This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Packaging

Packaged under argon

Preparation Note

Talsaclidine is soluble in DMSO at a concentration that is greater than 5 mg/ml.

Safety & Documentation

Safety Information

Symbol 
GHS05  GHS05
Signal word 
Danger
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Acetylcholine Receptors (Muscarinic)

Muscarinic acetylcholine receptors are members of the superfamily of G protein-coupled receptors (GPCRs). They are relatively abundant and mediate many of the diverse actions of acetylcholine in the ...
Keywords: Alzheimer Disease, Apoptosis, Atomic absorption spectroscopy, Gene expression, Hormones, Molecular biology, Neurotransmitters, Parkinson Disease, Polymorphisms, Transduction

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