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T3327 Sigma-Aldrich

Tubulysin A

≥95% (HPLC), from Streptomyces sp., film

Synonym: TubA

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Cytoskeleton and Extracellular Matrix,
Quality Level   100
biological source   Streptomyces sp.
assay   ≥95% (HPLC)
form   film
color   colorless to white
solubility   organic solvents: soluble
shipped in   wet ice
storage temp.   2-8°C
SMILES string   CC[C@H](C)[C@H](NC(=O)[C@H]1CCCCN1C)C(=O)N(COC(=O)CC(C)C)[C@H](C[C@@H](OC(C)=O)c2nc(cs2)C(=O)N[C@H](C[C@H](C)C(O)=O)Cc3ccc(O)cc3)C(C)C
InChI   1S/C43H65N5O10S/c1-10-27(6)38(46-40(53)34-13-11-12-18-47(34)9)42(54)48(24-57-37(51)19-25(2)3)35(26(4)5)22-36(58-29(8)49)41-45-33(23-59-41)39(52)44-31(20-28(7)43(55)56)21-30-14-16-32(50)17-15-30/h14-17,23,25-28,31,34-36,38,50H,10-13,18-22,24H2,1-9H3,(H,44,52)(H,46,53)(H,55,56)/t27-,28-,31+,34+,35+,36+,38-/m0/s1
InChI key   IBEDDHUHZBDXGB-OEJISELMSA-N

Description

Packaging

200 μg in glass bottle

Biochem/physiol Actions

Tubulysin A is a novel antibiotic, which is anti-microtubule, anti-mitotic, apoptosis inducer, anticancer, anti-angiogenic, and antiproliferative. Tubulysins are cytotoxic peptides, which include 9 members (A-I). Tubulysin A has potential application as an anticancer agent. It arrests cells in the G2/M phase. Tubulysin A inhibits polymerization more efficiently than vinblastine and induces depolymerization of isolated microtubules. Tubulysin A has potent cytostatic effects on various tumor cell lines with IC50 in the picomolar range.

Tubulysin A is a myxobacterial product that can function as an antiangiogenic agent in many in vitro assays1.

Preparation Note

Tubulysin A is soluble in organic solvents.

Safety & Documentation

Safety Information

Symbol 
GHS06  GHS06
Signal word 
Danger
Hazard statements 
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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