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T3932 Sigma-Aldrich

Tyrphostin AG 1295

≥98%

Synonym: 6,7-Dimethyl-2-phenylquinoxaline

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Properties

assay   ≥98%
solubility   0.1 M HCl: soluble <1 mg/mL
  ethanol: soluble 10 mg/mL
  methylene chloride: soluble 10 mg/mL
  0.1 M NaOH: insoluble
  2-hydroxypropyl-β-cyclodextrin: insoluble
  H2O: insoluble
storage temp.   −20°C
Gene Information   human ... EGFR(1956), FLT3(2322), PDGFRB(5159), SRC(6714)
mouse ... Pdgfrb(18596)

Description

Application

Tyrphostin AG 1295 has been used as an Flt3 inhibitor in NA10 and ND13 progenitor cell lines2. Studies using AG 1295 have reported that it can reduce cell division and DNA synthesis induced by nicotine in human aortic vascular smooth muscle cells3.

Tyrphostin AG 1295 is soluble in methylene chloride at 10 mg/ml, in ethanol at 10 mg/ml and in 0.1 N HCl at less than 1 mg/ml. It is however, insoluble in water, 0.1 N sodium hydroxide, and 2-hydroxypropyl-β-cyclodextrin.

Biochem/physiol Actions

Studies in mouse osteoblastic MC3T3-E1 cells have reported that AG 1295 can enhance matrix mineralization and osteoblast differentiation by inhibiting PDGFR-β signaling4.

Selective inhibitor of tyrosine kinase in platelet-derived growth factor (PDGF) receptor.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

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Protocols & Articles
Peer-Reviewed Papers
15

References

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