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T4943 Sigma-Aldrich

Tyrphostin AG 556

≥98%

Synonym: N-(4-Phenylbutyl)-3,4-dihydroxybenzylidenecyanoacetamide, Tyrphostin B56

  • CAS Number 133550-41-1

  • Empirical Formula (Hill Notation) C20H20N2O3

  • Molecular Weight 336.38

  •  MDL number MFCD00209860

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Properties

assay   ≥98%
potency   >500 μM IC50 (EGFR activity)
  1.1 μM IC50 (HER1-2 kinase activity)
solubility   DMSO:methanol (1:1): soluble 10 mg/mL, clear, yellow
  DMSO: soluble
storage temp.   −20°C

Description

Biochem/physiol Actions

Tyrphostin AG 556 is known to enhance survival and decrease multi-organ failure in canine models of gram-negative septic shock1. Furthermore, studies in rat models have reported that tyrphostin AG 556 can decrease the size of a myocardial infarct and alleviate hemodynamic deterioration2.

Highly selective EGFR protein tyrosine kinase inhibitor.

Preparation Note

Tyrphostin AG 556 is soluble in DMSO:Methanol (1:1) at 10 mg/ml and yields a clear, yellow solution.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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