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T5575 Sigma-Aldrich

TG003

≥98% (HPLC)

Synonym: (Z)-1-(3-Ethyl-5-methoxy-2,3-dihydrobenzothiazol-2-ylidene)propan-2-one

  • CAS Number 300801-52-9

  • Empirical Formula (Hill Notation) C13H15NO2S

  • Molecular Weight 249.33

  •  MDL number MFCD00624584

  •  PubChem Substance ID 24278611

  •  NACRES NA.77

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Properties

Related Categories A to C, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Biochemicals and Reagents, Cdc2-like Kinase,
Quality Level   100
assay   ≥98% (HPLC)
form   powder
color   white to beige
mp   132-132.5 °C
solubility   DMSO: 33 mg/mL
storage temp.   2-8°C
SMILES string   CCN1\C(Sc2ccc(OC)cc12)=C\C(C)=O
InChI   1S/C13H15NO2S/c1-4-14-11-8-10(16-3)5-6-12(11)17-13(14)7-9(2)15/h5-8H,4H2,1-3H3/b13-7-
InChI key   BGVLELSCIHASRV-QPEQYQDCSA-N

Description

Application

TG003 has been used in PAC1 cell culture and in vitro kinase assays.

TG003 has been used to develop assays for screening substances that affect mRNA splicing1.

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

TG003 regulates alternative splicing and reduces the phosphorylation of SF2/ASF1.

TG003, a CLK (cdc2-like kinase) family inhibitor is used as a drug for duchenne muscular dystrophy.

Potent, specific, reversible, and ATP-competitive inhibitor of Cdc2-like kinase (Clk). Ki = 10 nM for mClk1/Sty; IC50 = 15 nM, 20 nM, 200 nM, and > 10 mM for mClk4, mClk1, mClk2, and mClk3, respectively.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

Packaging

Packaged under nitrogen.

Preparation Note

TG003 is soluble in DMSO at 33 mg/ml.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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