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T6397 Sigma-Aldrich

3,3′,5-Triiodo-L-thyronine sodium salt

powder, BioReagent, suitable for cell culture

Synonym: Liothyronine, O-(4-Hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine sodium salt, T3

  • CAS Number 55-06-1

  • Empirical Formula (Hill Notation) C15H11I3NNaO4

  • Molecular Weight 672.96

  •  Beilstein/REAXYS Number 8179867

  •  EC Number 200-223-5

  •  MDL number MFCD00002594

  •  PubChem Substance ID 24900372

  •  NACRES NA.77

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Properties

Related Categories Cell Biology, Cell Culture, Cell Signaling and Neuroscience, Cytokines, Growth Factors and Hormones, Hormones,
Quality Level   200
biological source   synthetic
product line   BioReagent
assay   ≥95%
form   powder
potency   0.02-50 ng/mL (lit.)
application(s)   cell culture | mammalian: suitable
solubility   ethanol/1 M HCl (4:1): 10 mg/mL, clear, colorless to yellow
shipped in   ambient
storage temp.   −20°C
SMILES string   [Na+].N[C@@H](Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1)C([O-])=O
InChI   1S/C15H12I3NO4.Na/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22;/h1-4,6,12,20H,5,19H2,(H,21,22);/q;+1/p-1/t12-;/m0./s1
InChI key   SBXXSUDPJJJJLC-YDALLXLXSA-M
Gene Information   human ... THRA(7067), THRB(7068)
rat ... Thra(81812), Thrb(24831)

Description

General description

3,3′,5′-Triiodo-L-thyronine (T3) is an endocrine hormone produced by the thyroid gland and is regarded as an active thyroid hormone at cellular level. Thyroxine (T4) serves as a precursor for T3 and is generated in extrathyroidal tissues.

Application

3,3′,5-Triiodo-L-thyronine sodium salt has been used for inducing thyroid hormone manipulations in mice. It has also been used In cell culturing of hippocampal, retinal, proximal tubule and glomerular explant.

Biochem/physiol Actions

3,3′,5′-Triiodo-L-thyronine (T3) increases the rates of protein synthesis, stimulates the breakdown of cholesterol and effects embryonic development. In cell culture, T3 regulates cell differentiation and protein expression. The interaction of T3 with nonhistone proteins in the chromatin initiates the thyroid hormone activity. Thyroid hormones regulate the differentiation and development of tissues and affect a number of metabolic processes. The level of circulating T3 hormone is reduced in hypothyroidism.

Physical form

powder-0 °C; stock-frozen in working aliquots, avoid repeated freeze/thaw, solution stable 2-8 °C, 30 days

Reconstitution

To prepare 20 μg/ml stock solution: add 1ml 1N NaOH per mg 3,3′, 5-triiodo-L-thyronine; gently swirl to dissolve. To this, add 49 ml sterile medium per ml 1N NaOH added.

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles

Articles

HPLC Analysis of Levothyroxine and Liothyronine on Ascentis® Express ES-Cyano

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Levothyroxine and Liothyronine on Ascentis® Express ES-Cyano
Keywords: Chromatography, Clinical, High performance liquid chromatography, Hormones

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Peer-Reviewed Papers
15

References

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