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T7508 Sigma-Aldrich

Tetracaine hydrochloride

≥99%

Synonym: 4-(Butylamino)benzoic acid 2-(dimethylamino)ethyl ester, Amethocaine hydrochloride

  • CAS Number 136-47-0

  • Empirical Formula (Hill Notation) C15H24N2O2 · HCl

  • Molecular Weight 300.82

  •  MDL number MFCD00038912

  •  PubChem Substance ID 57654697

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Ion Channels,
InChI Key   PPWHTZKZQNXVAE-UHFFFAOYSA-N
assay   ≥99%
solubility   chloroform: soluble 30 parts
  alcohol: soluble 40 parts
  H2O: soluble mg/mL
  acetone: insoluble
  benzene: insoluble
  diethyl ether: insoluble

Description

Application

Tetracaine hydrochloride has been used for studying the pharmacological effects of spinal anesthesia. Tetracaine hydrochloride has also been used as a component of protease digestion buffers.

Topical ophthalmic anesthetic; used for spinal anesthesia

Packaging

5, 25, 100 g in poly bottle

Biochem/physiol Actions

Blocks voltage-sensitive release of Ca2+ from sarcoplasmic reticulum.

Features and Benefits

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

This compound is featured on the Cyclic Nucleotide-Gated (CNG) and Hyperpolarization Activated Cyclic Nucleotide-Gated (HCN) Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Preparation Note

Tetracaine hydrochloride dissolves in water at 50 mg/ml to yield a clear, colorless solution. It is also soluble in 40 parts alcohol and 30 parts chloroform. However, it is practically insoluble in ether benzene or acetone.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

Symbol 
GHS06  GHS06
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3

Documents

Certificate of Analysis

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Certificate of Origin

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Making Headway

Milli-Q® Water Purification Solutions
Protocols & Articles

Articles

Discover Bioactive Small Molecules for Cyclic Nucleotides

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Keywords: Antivirals, Cancer, Cardiovascular, Cellular processes, Diabetes, Diseases, Hormones, Neurotransmitters

Peer-Reviewed Papers
15

References

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