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T7580 Sigma-Aldrich

TN-16

≥98% (HPLC)

Synonym: 3-[1-(Phenylamino)ethylidene]-5-(phenylmethyl)-2,4-pyrrolidinedione, NSC 239274

  • CAS Number 33016-12-5

  • Empirical Formula (Hill Notation) C19H18N2O2

  • Molecular Weight 306.36

  •  PubChem Substance ID 329826871

  •  NACRES NA.77

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Properties

Related Categories BMPs and Receptors, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience,
Quality Level   100
assay   ≥98% (HPLC)
form   powder
color   white to tan
solubility   DMSO: ≥17 mg/mL
storage temp.   2-8°C
SMILES string   C\C(Nc1ccccc1)=C2\C(=O)NC(Cc3ccccc3)C2=O
InChI   1S/C19H18N2O2/c1-13(20-15-10-6-3-7-11-15)17-18(22)16(21-19(17)23)12-14-8-4-2-5-9-14/h2-11,16,20H,12H2,1H3,(H,21,23)/b17-13-
InChI key   KWSXUGYAGMSUTN-LGMDPLHJSA-N

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

Inhibitor of microtubule assembly

TN-16 is a synthetic compound that blocks the assembly, and promotes the dissociation of microtubules. TN-16 has been shown to prevent the b-TrCP-mediated degradation of the transcription factor Gli2, leading to the up-regulation of BMP-2 and supporting a role for microtubule formation in the regulation of bone formation.

Safety & Documentation

Safety Information

Symbol 
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Discover Bioactive Small Molecules for Cytokines & Growth Factors Research

Cytokines and growth factors (GF) are chemical messengers that mediate intracellular communication, thereby regulating cellular and nuclear functions. These chemical messengers bind cell surface rece...
Keywords: Biological processes, Cancer, Cell proliferation, Diseases, Growth factors, Ligands, Phosphorylations, Transcription, Transduction

Peer-Reviewed Papers
15

References

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