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T8902 Sigma-Aldrich

Thiostrepton from Streptomyces azureus

≥90% (HPLC)

  • CAS Number 1393-48-2

  • Empirical Formula (Hill Notation) C72H85N19O18S5

  • Molecular Weight 1664.89

  •  EC Number 215-734-9

  •  MDL number MFCD00135828

  •  PubChem Substance ID 24900569

  •  NACRES NA.77

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Properties

Related Categories Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics T-Z, Antibiotics by Application,
InChI Key   NSFFHOGKXHRQEW-BXVAPQLOSA-N
assay   ≥90% (HPLC)
solubility   acetic acid: soluble 25 mg/mL, clear to hazy, yellow to brownish-yellow
Mode of action   protein synthesis | interferes
antibiotic activity spectrum   Gram-negative bacteria
  Gram-positive bacteria
  parasites
storage temp.   −20°C

Description

General description

Chemical structure: peptide

Packaging

1 g in poly bottle

Application

Thiostrepton has been used as a selectable marker for recombinant Streptomyces cultures,,.

Biochem/physiol Actions

Peptide antibiotic that prevents the binding of elongation factor G (EF-G) and GTP to the 50S ribosomal subunit.

Preparation Note

Thiostrepton dissolves in acetic acid at 25 mg/ml to yield a clear to hazy, yellow-yellow brown solution.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
XN6300100

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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