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T9033 Sigma-Aldrich

Thapsigargin

≥98% (HPLC), solid film

  • CAS Number 67526-95-8

  • Empirical Formula (Hill Notation) C34H50O12

  • Molecular Weight 650.75

  •  MDL number MFCD00083511

  •  PubChem Substance ID 24278762

  •  NACRES NA.77

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Properties

Related Categories A to C, Adenosinetriphosphatase (microsomal calcium), Antitumor Agents, Autophagy, Autophagy Inhibitors,
Quality Level   300
assay   ≥98% (HPLC)
form   solid film
solubility   acetonitrile: soluble 9.80-10.20 mg/mL
  DMSO: soluble
  ethanol: soluble
storage temp.   −20°C
SMILES string   [H][C@@]12C([C@H](OC([C@]3(O)C)=O)[C@]3(O)[C@@H](OC(CCC)=O)C[C@]2(C)OC(C)=O)=C(C)[C@H](OC(/C(C)=C(C)/[H])=O)[C@H]1OC(CCCCCCC)=O
InChI   1S/C34H50O12/c1-9-12-13-14-15-17-24(37)43-28-26-25(20(5)27(28)44-30(38)19(4)11-3)29-34(41,33(8,40)31(39)45-29)22(42-23(36)16-10-2)18-32(26,7)46-21(6)35/h11,22,26-29,40-41H,9-10,12-18H2,1-8H3/b19-11-/t22-,26+,27-,28-,29-,32-,33+,34+/m0/s1
InChI key   IXFPJGBNCFXKPI-FSIHEZPISA-N

Description

Biochem/physiol Actions

Potent, cell-permeable, IP3-independent intracellular calcium releaser. Blocks the transient increase in intracellular Ca2+ induced by angiostatin and endostatin. Induces apoptosis by disrupting intracellular free Ca2+ levels; incorporated into chemotherapeutic prodrug formulations.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

Legal Information

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Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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