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V4390 Sigma-Aldrich

VUF 8430 dihydrobromide

≥97% (NMR)

Synonym: 2-[(Aminoiminomethyl)amino]ethyl carbamimidothioic acid ester, S-(2-guanidylethyl)-isothiourea

  • CAS Number 100130-32-3

  • Empirical Formula (Hill Notation) C4H11N5S· 2HBr

  • Molecular Weight 323.05

  •  MDL number MFCD01694605

  •  PubChem Substance ID 329829051

  •  NACRES NA.77

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Properties

Related Categories Agonists, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience,
Quality Level   100
assay   ≥97% (NMR)
form   solid
storage condition   desiccated
solubility   deionized water: 24 mg/mL
storage temp.   room temp
SMILES string   Br.Br.NC(=N)NCCSC(N)=N
InChI   1S/C4H11N5S.2BrH/c5-3(6)9-1-2-10-4(7)8;;/h1-2H2,(H3,7,8)(H4,5,6,9);2*1H
InChI key   GPWJSTKHQMIXCA-UHFFFAOYSA-N

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

VUF 8430 dihydrobromide is a potent histamine H4 receptor agonist, with a 33-fold selectivity over the histamine H3 receptor and negligible affinity for the other histamine receptor.

Features and Benefits

This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Target organs 
Respiratory system
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
RTECS 
UM6960000
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Histamine Receptors

The biogenic amine histamine plays an important role in a variety of pathophysiological conditions. In peripheral tissues, histamine is mainly stored in mast cells and basophils. In allergic conditio...
Keywords: Alzheimer Disease, Atomic absorption spectroscopy, Cardiovascular, Clinical, Diseases, Gene expression, Inflammation, Ligands, Neurotransmitters, Obesity, Transduction

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