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W102 Sigma-Aldrich

(R)-(+)-WIN 55,212-2 mesylate salt

≥98% (HPLC)

Synonym: (R)-(+)-[2,3-Dihydro-5-methyl-3[(4-morpholinyl)methyl]pyrrolo[1,2,3-de]-1,4-benzoxazinyl]-(1-naphthalenyl)methanone mesylate salt, WIN 55212-2 methanesulfonate, WIN 552122 mesylate

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cannabinoids, Cell Biology, Cell Signaling and Neuroscience,
InChI Key   FSGCSTPOPBJYSX-VEIFNGETSA-N
assay   ≥98% (HPLC)
form   powder
drug control   regulated under CDSA - not available from Sigma-Aldrich Canada
color   white to beige
solubility   0.1 M HCl: 0.25 mg/mL
  DMSO: 12 mg/mL
  45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 2.4 mg/mL
  0.1 M NaOH: insoluble
  H2O: insoluble
Gene Information   human ... CNR1(1268), CNR2(1269)

Description

Packaging

100 mg in glass bottle

25 mg in poly bottle

Legal Information

Sold with the permission of Sterling-Winthrop, Inc.

Application

(R)-(+)-WIN 55,212-2 mesylate salt has been used as a high affinity cannabinoid agonist for intraperitoneal injection into rats to induce behavioural sensitization. It has also been used as a synthetic cannabinoid drug and cannabinoid receptor 1 (CNR1) agonist to treat Becn2+/− mice and wild-type (WT) littermate to analyze the levels of CNR1 in the brain.

Biochem/physiol Actions

It is known to decrease the lipopolysaccharide mediated release of tumor necrosis factor- α and interleukin-1 in mice.

Features and Benefits

This compound is featured on the Cannabinoid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

General description

WIN 55,212-2 is a member of the aminoalkylindole class of compounds.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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