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Z4902 Sigma-Aldrich

ZD 7114 hydrochloride

≥98% (HPLC)

Synonym: Acetamide, 2-[4-[2-[[(2S)-2-hydroxy-3-phenoxypropyl]amino]ethoxy]phenoxy]-N-(2-methoxyethyl)-, ICI D7114

  • CAS Number 129689-28-7

  • Empirical Formula (Hill Notation) C22H30N2O6 · HCl

  • Molecular Weight 454.94

  •  MDL number MFCD00902237

  •  PubChem Substance ID 329831619

  •  NACRES NA.77

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Properties

Related Categories Adrenergics, Agonists, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology,
Quality Level   100
assay   ≥98% (HPLC)
form   powder
optical activity   [α]/D -10.7°, c = 1.0 in methanol
color   white to off-white
solubility   H2O: >20 mg/mL
storage temp.   2-8°C
SMILES string   Cl.COCCNC(=O)COc1ccc(OCCNC[C@H](O)COc2ccccc2)cc1
InChI   1S/C22H30N2O6.ClH/c1-27-13-12-24-22(26)17-30-21-9-7-20(8-10-21)28-14-11-23-15-18(25)16-29-19-5-3-2-4-6-19;/h2-10,18,23,25H,11-17H2,1H3,(H,24,26);1H/t18-;/m0./s1
InChI key   KCAMZVQSGDBGGF-FERBBOLQSA-N

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

ZD 7114 is a selective β3 adrenergic receptor agonist. β3 adrenoceptors are expressed in adipose tissue and smooth muscle.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

This compound is featured on the β-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

Symbol 
GHS09  GHS09
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

β-Adrenoceptors

β-Adrenoceptors are widely distributed, found at both central and peripheral sites, and are activated either via norepinephrine released from sympathetic terminals or via epinephrine (E4250, E4375) r...
Keywords: Antihypertensives, Atomic absorption spectroscopy, Diabetes, Gene expression, Neurotransmitters, Obesity, Reductions, Transduction

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