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A0298 Sigma-Aldrich

Adrenocorticotropic Hormone Fragment 1-24 human, rat

≥97% (HPLC)

Synonym: Tetracosactide

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Properties

Related Categories Adrenocorticotrophic Hormone (ACTH), Adrenocorticotropic Hormones (ACTH), Cell Biology, Cell Signaling and Neuroscience, Cytokines, Growth Factors and Hormones,
Quality Level   200
assay   ≥97% (HPLC)
composition   Peptide content, ≥60%
storage temp.   −20°C
SMILES string   CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc4c[nH]c5ccccc45)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N6CCC[C@H]6C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N7CCC[C@H]7C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc8ccc(O)cc8)C(=O)N9CCC[C@H]9C(O)=O
InChI   1S/C136H210N40O31S/c1-75(2)109(127(200)154-71-106(181)156-88(31-13-17-52-137)114(187)158-89(32-14-18-53-138)115(188)159-91(35-21-56-149-134(142)143)116(189)164-96(37-23-58-151-136(146)147)131(204)175-60-25-39-104(175)126(199)173-111(77(5)6)128(201)163-90(33-15-19-54-139)120(193)171-110(76(3)4)129(202)169-101(65-80-43-47-84(180)48-44-80)132(205)176-61-26-40-105(176)133(206)207)172-125(198)103-38-24-59-174(103)130(203)95(34-16-20-55-140)157-107(182)70-153-113(186)99(66-81-68-152-87-30-12-11-29-85(81)87)167-117(190)92(36-22-57-150-135(144)145)160-121(194)98(63-78-27-9-8-10-28-78)166-123(196)100(67-82-69-148-74-155-82)168-118(191)93(49-50-108(183)184)161-119(192)94(51-62-208-7)162-124(197)102(73-178)170-122(195)97(165-112(185)86(141)72-177)64-79-41-45-83(179)46-42-79/h8-12,27-30,41-48,68-69,74-77,86,88-105,109-111,152,177-180H,13-26,31-40,49-67,70-73,137-141H2,1-7H3,(H,148,155)(H,153,186)(H,154,200)(H,156,181)(H,157,182)(H,158,187)(H,159,188)(H,160,194)(H,161,192)(H,162,197)(H,163,201)(H,164,189)(H,165,185)(H,166,196)(H,167,190)(H,168,191)(H,169,202)(H,170,195)(H,171,193)(H,172,198)(H,173,199)(H,183,184)(H,206,207)(H4,142,143,149)(H4,144,145,150)(H4,146,147,151)/t86-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,109-,110-,111-/m0/s1
InChI key   ZOEFCCMDUURGSE-SQKVDDBVSA-N
Gene Information   human ... MC2R(4158), POMC(5443)

Description

Amino Acid Sequence

Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro

General description

Adrenocorticotropic hormone (ACTH), also called proopiomelanocortin (POMC), is a 303-amino acid hormone protein. Proteolysis of ACTH results in active peptides. ACTH is mapped to human chromosome 2p23.3.

The portion of the ACTH sequence that is conserved across species; has ~75% of the potency of ACTH on a molar basis.

Application

Adrenocorticotropic Hormone Fragment 1-24 human, rat, has been used in corticosterone enzyme immunoassay and to induce color change in frogs.

Biochem/physiol Actions

Activates G proteins.

Adrenocorticotropic hormone (ACTH) activates melanocortin receptor (MC1R to MC5R) and plays a key role in generation of α-melanocyte-stimulating hormone (α-MSH). The loss of function mutations in ACTH gene is implicated in obesity and red hair. Hypomethylation of POMC promoter region in thymic carcinoids is associated with ectopic adrenocorticotropic hormone syndrome. POMC mutation results in generation of abnormal fusion protein, impairing melanocortin signalling in hypoadrenalism. Dysregulation of ACTH gene transcription impacts metabolic pathways leading to Cushing disease.

Other Notes

Lyophilized from 0.1% TFA in H2O

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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92210 Timestrip Plus 0 °C
06693 Timestrip Plus -20 °C

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