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A0423 Sigma-Aldrich

Adrenocorticotropic Hormone human

≥97% (HPLC)

Synonym: Adrenocorticotropic hormone fragment 1-39, Corticotropin A

  • CAS Number 12279-41-3

  • Empirical Formula (Hill Notation) C207H308N56O58S

  • Molecular Weight 4541.07

  •  MDL number MFCD00145721

  •  NACRES NA.32

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Properties

Related Categories Adrenocorticotrophic Hormone (ACTH), Adrenocorticotropic Hormones (ACTH), Cell Biology, Cell Signaling and Neuroscience, Cytokines, Growth Factors and Hormones,
Quality Level   200
assay   ≥97% (HPLC)
form   powder
solubility   water: 1.00-1.04 mg/mL, clear, colorless
shipped in   ambient
storage temp.   −20°C
InChI key   IDLFZVILOHSSID-OVLDLUHVSA-N
Gene Information   human ... POMC(5443)

Description

Amino Acid Sequence

Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro-Asn-Gly-Ala-Glu-Asp-Glu-Ser-Ala-Glu-Ala-Phe-Pro-Leu-Glu-Phe

General description

Adrenocorticotropic hormone (ACTH) is a 303-amino acid hormone protein, which is located at human chromosome 2p23.3.

Biochem/physiol Actions

Adrenocorticotropic hormone (ACTH) stimulates melanocortin receptor (MC1R to MC5R).It is implicated in the production of α-melanocyte-stimulating hormone (α-MSH). Hypomethylation of ACTH promoter region in thymic carcinoids is associated with ectopic adrenocorticotropic hormone syndrome. Mutations in this gene are associated with aberrant fusion protein and impairing melanocortin signaling in hypoadrenalism. Dysregulation of ACTH leads to Cushing disease.

Stimulates synthesis and secretion of glucocorticoids by adrenal cortex.

Other Notes

Lyophilized from 0.1% TFA in H2O

Safety & Documentation

Safety Information

Symbol 
Signal word 
Warning
Hazard statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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